In February 2018, the Conrad N. Hilton Foundation convened the Youth SBIRT Research Roundtable: Current Status and Future Directions. The purpose of this two-day, small group meeting was to inform the Hilton Foundation’s Substance Use Prevention Strategic Initiative by reviewing the current status of research and practice and identifying key gaps and opportunities to expand the knowledge base and scale-up evidence-based implementation of Screening, Brief Intervention and Referral to Treatment (SBIRT) services.