The Conrad N. Hilton Foundation awarded a grant in September 2014 to the Trust for America’s Health (TFAH) to examine how to help move towards a strong prevention-oriented, continuum-of-care approach to substance misuse — looking at policies and programs that have a high impact for improving the well-being of America’s youth. This report, which came out in November 2015, provides the public, policymakers and a broad and diverse set of partners with an objective, nonpartisan, independent analysis of the status of youth development policies; encourages greater transparency and accountability; and recommends ways to ensure the public health system and partners can work together across boundaries to accomplish the shared objective of preventing and reducing teen substance misuse.